Alzheimer Disease-NetPro | Molecular Connections

Alzheimer Disease-NetPro | Molecular Connections

Alzheimer disease, the most common cause of senile dementia is a progressive neurodegenerative disease characterized by loss of memory and cognition. The major neuropathologic features of Alzheimer disease (AD) include formation of amyloid plaques and Neurofibrillary tangles in certain regions of the brain. Even a century after the discovery of this disease, the drugs available can only alleviate the disease symptoms but there is no available drug that can actually stop the progression of the disease. The current analysis is aimed at generating an interaction network depicting the plausible molecular events leading to the development of the disease condition and narrowing down on molecules that might be important targets or therapeutic agents for this disease, based on the network generated. Towards this, data from a commercially available bi-molecular interaction database NetPro^TM that contains high quality manually curated protein-protein and protein-small molecule interactions, was used to understand interaction network(s) of a set of genes, specifically shown to be differentially regulated in Alzheimer disease patients in a microarray study done by Colangelo V et al (2002)¹